Gamechangers

We address public health needs by developing a self-amplifying RNA-based platform for rapid and scalable manufacturing of innovative medical tools.

Our Technology

Lipid nanoparticle
(LNP) 

The in-house developed LNP library at Ziphius is specifically designed for saRNA delivery, ensuring proper encapsulation, stability, and biodegradability of the LNP-saRNA complex. Ziphius is also focused on developing LNPs for various administration routes across a range of therapeutic applications. The platform is being optimized to achieve optimal efficacy in infectious disease vaccines, therapies for rare diseases and oncology.

 

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Self-amplifying RNA
(saRNA)

Over conventional RNA, saRNA has the unique ability to replicate itself, thereby amplifying the number of coding sequences from a single molecule. SaRNAs are thus expected to induce higher amounts of the protein of interest at a much lower dosage and for a longer duration. For vaccines, this can translate into longer protection than the conventional RNA vaccines along with enhanced immune memory. In the case of rare diseases, saRNA could bring a long-term expression of the deficient or replacement protein, offering a new therapeutic modality with a convenient administration schedule. In oncology, saRNA offers diverse applications, ranging from personalised cancer vaccines to the expression of chimeric antigen receptors (CARs) on immune cells for use in immunotherapy.

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Pipeline

Ziphius aims to leverage the use of its self-amplifying RNA platform to develop innovative solutions across a range of applications, from infectious disease prevention to advanced therapies for rare diseases and next-generation oncology treatments.

Ziphius

Join our team

Ziphius’ team consists of a well-balanced group of people with complementary skills and a background ranging from biology, virology, chemistry till pharmaceutical sciences. The team members are united by their common passion for science, health care, innovation and entrepreneurship.

Latest news

Upcoming

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Bio€quite Europe
Bruges, Belgium
Bio NJ
New Jersey, USA
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BIO US
Boston, USA
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World Vaccine Congress Europe
Amsterdam, Netherlands