We address public health needs by developing a self-amplifying RNA-based platform for rapid and scalable manufacturing of innovative medical tools.

Our Technology

Lipid nanoparticle

The in-house developed LNP library at Ziphius is specifically designed for saRNA delivery and ensures proper encapsulation, stability, and biodegradability of the LNP-saRNA complex. Furthermore, Ziphius is also focused on making LNPs for various administration routes for vaccination and supplementation therapies. The platform is being optimized to target specific organs and tissues, to minimize acute and chronic toxicity, and to acquire the most optimal prophylactic vaccination or gene supplementation effect.


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Self-amplifying RNA

Over conventional mRNA, saRNA contains the replicating capability to amplify the copy number of coding sequences from a single transcript. saRNAs are able to carry larger sequences while generating more RNA. saRNAs are then expected to induce equal or higher required ‘product’ at a much lower dosage.

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Ziphius aims to leverage the use of its self-amplifying RNA platform to create vaccines for the prevention of infectious diseases and gene supplementation therapies for rare genetic disorders.


Join our team

Ziphius Vaccines’ team consists of a well-balanced group of people with complementary skills and a background ranging from biology, virology, chemistry till pharmaceutical sciences. The team members are united by their common passion for science, health care, innovation and entrepreneurship.

Latest news


BIO-Europe Spring
Barcelona, Spain
European Cystic Fibrosis Society
Valletta, Malta
Global Investor Forum
Rotterdam, Netherlands
World Vaccine Congress Washington 2024
Washington, USA
Venture Summit West
Silicon Vally, USA
17th Kempen Life Sciences Conference
Amsterdam, Netherlands
JP Morgan European Healthcare Conference
Brussels, Belgium
BioTrinity 2024
London, UK
Formulation UK 2024 Congress
London, UK
24th Bio€quity Europe
San Sebastian, Spain
New York 2023 Venture Capital World Summit
New York, USA
Knowledge For Growth
Antwerp, Belgium